A famous parable demonstrates how truth is relative: A wise man guides four blind people to describe an object. They are led to an Asian elephant. Groping about, they try to appreciate and explain the new phenomenon. One grasps the trunk and concludes it is a snake. Another explores one of the elephant’s legs and describes it as a tree. A third finds the elephant’s tail and announces that it is a rope. The fourth blind man, after discovering the elephant’s side, concludes it’s a wall.
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GM pharming
Genetically modified crops have already come up against the brick wall of public opinion in Britain. The original movement to produce food crops genetically modified to be immune or resistant to herbicides or pests, or both, resulted in a huge media and public backlash.
Scientists have long looked for ways to bring down the high costs of the extant procedures for drug production used by the world’s pharmaceutical industry. Big pharma companies’ bottom lines dictate that drug production tends to favour those parts of the world and sections of society which can turn medicines into profits. Pharming could turn that situation on its head.
Many feel that in order to sustain the levels of growth required for pharming to work it will be necessary to downgrade these security requirements and perhaps start growing proteins, for cheaper and quicker results, in food crops. The major benefit of pharming would be scale, but this last step may prove a major stumbling block. The possibility that GM crops pharmed to produce human proteins could escape into the food chain and contaminate entire food crops, is too large a risk for most.
Cell division
Embryonic stem cell research has divided the world. For some, it represents the future of medical science, for others, the end of human dignity. Whatever the ethical concerns, it represents a massive commercial opportunity for biotech companies. And for countries that come down on the right side of the divide, a big boost to the economy.
The UK biotech industry is growing. Though it still lags some way behind its American competitors, it is enjoying better health today than it has ever sustained before. Last year, biotech investment in the UK and Europe rose by 20 percent to 1.4bn, reflecting a new era of stability for the industry.
Barring the mini-boom of investment some five years ago, fuelled partly by the hype surrounding the human genome project, the pioneering days of the industry saw very little investment, and when the bubble burst on the overvalued science of the HGP, the biotech start-ups were once again painfully short of money, leaving some of the industry’s most talented scientists out of jobs.
As low-tech manufacturing drifted east, the UK government focussed more and more on the ‘knowledge economy’ and the manufacture of high-tech and scientific products. Extra government spending and increased investment helped nurture biotechnology through a long and tentative recovery period. Investor confidence has now finally returned, largely in response to biotechs taking better account of commercial demands and focussing on projects with shorter lead times. But it is partly this commercial maturity – and scientific conservatism – that has left potentially vast wells of investment into controversial embryonic stem cell research untapped. The research promises to test the parameters of bio-medical ethics, and most of the newly commercialised biotechs have been unable to steel themselves to enter this dangerous and confusing moral landscape before legal, regulatory and intellectual property issues have been resolved.
The potential impact of his findings could hardly be exaggerated. It was a discovery that in any other field would have resulted in a major federal research project. Instead, it sparked a violent dispute about human life and human progress that spread around the world. The big decisions over stem cell research have since been wrestled from the hands of scientists. The progress made is no longer to be decided by dithering biotech companies or their reluctant investors. The decision belongs to the policymakers and governments of the world. It is for them to draw the line, to mark the limits of progress and of moral behaviour, and many have already made their decisions.
Thomson’s announcement dragged biotechnology into a maelstrom of religious and political arguments. Religious leaders, congressmen, and finally the Oval Office wanted to know where the needed embryos would come from and how many would be consumed by the demand of the world’s sick. Many in the US insisted that embryos are just as fully members of society as adult humans, and that their vulnerability demands they be protected more than most. Some compared the harvesting of embryonic cells to cannibalism and hyperbolic phrases like ’embryo farms’ and ‘cloning mills’ became commonplace. The same reaction was repeated in many other countries, as religious and moral anger raged across the globe.
The attitudes of those opposed to the research were summed up by a Greenpeace protest against human embryo patents outside the Reichstag in Germany. Protesters carrying placards with the uncompromising slogan ‘Stoppt Patente Auf leben’ marched around hundreds of frozen blocks of ice, each one with a plastic baby doll inside. The Greenpeace representatives were probably aware (unlike many of those who saw their protest) that the embryos being discussed were no bigger than the full point at the end of this sentence. They have no identifying features, and not even the merest hint of a nervous system. But shock tactics are from rare when discussing issues as important and emotive as this.
Richard Branson has just launched a much-publicised Virgin-branded cold-storage operation where parents can store their newborn’s umbilical cord and placental blood for use in later life. The stem cells thereby retained could be used to grow tissue or organs much less likely to be rejected by the body than cells imported from another donor, and the project might prove to have huge medical potential. But research carried out on pigs and mice suggests these types of stem cell could not match the versatility of embryonic stem cells, which have already been used to replace injured or dead cells in these animals to cure heart disease, diabetes, spinal cord injuries and many more afflictions. Research on human embryonic stem cells could yet prove to be modern medical science’s biggest discovery.
Clearly, this area could be a potential goldmine for biotechnology, and crucially – given the massive polarity of views globally – a chance for biotechnology to find strongholds in the scientifically liberal countries willing to embrace, promote and invest in the resulting technologies. Branson’s step is a brave one. Private storage, of the type he is offering, is opposed by the EC’s European Group on Ethics in Science and New Technologies and is now unlawful in France and Italy. But Branson’s courtship of controversy might be just what biotechnology needs. Much of the discussion and legislation surrounding stem cell research so far has been squeamish of commercialism to say the very least. Of course Branson has tried to show that his motivation in this venture, as with the research he is privately funding into biofuels, is born of corporate conscience – half of the donated blood will be stored in a national bank for research purposes – but the company will be run for profit. And biotechs can’t afford to be afraid of turning profit from progress.
Boundaries, of course, have been drawn, but the UK is keen to achieve the best results possible within the parameters of public approval. To that end, Science and Innovation Minister Malcolm Wicks has announced that the UK’s two major public funders of stem cell research, the Biotechnology and Biological Sciences Research Council and the Medical Research Council (MRC), will run a national public discussion on the issue funded by the Sciencewise unit of the DTI. The dialogue programme will aim to bring scientists and the public together to identify public expectations, aspirations and concerns about stem cell research, and will be paid for by a £300,000 government grant. When the announcement was made at a meeting of leading experts in the field in London recently MRC Chief Executive, Colin Blakemore, made it clear that the dialogue was as much about moving forward as gauging opinion. He said: “Discussion will help to make scientists understand the potential of their work and policymakers aware of the public’s views. In turn, this might lead to laboratory discoveries being applied more quickly in the clinic.”
Green giants
One of the main drivers behind companies’ decisions to go ‘green’ is to reduce the environmental impact of business operations by cutting down their greenhouse gas emissions. This is the case even if a company’s facilities are not currently capped under the EU Emissions Trading Scheme. Other benefits include diversifying energy supplies and hedging from fluctuating fossil fuel prices, as well as strengthening a company’s stakeholder relationships and differentiating its brand.
Conspiracy theories through the ages
Politics has had many faces and faced many different dilemmas. Since Plato’s Republic, man has wrestled in the political arena, pointed fingers, shifted blame, and concealed various daggers behind manifold cloaks. The New Economy investigates some o f the recent theories that have influenced, determined, scarred and decimated the political world
A new world order?One of a number of theories that refer to a secretive group that aims to rule the world with an autonomous, omnipresent government. The backbone of the New World Order theory is that an organisation of the world’s elite have made plans to draw forces together and usurp power from all other states.
Bilderbergers supersized
Trotsky killed in cold blood August 21, 1940 – Many questions arose soon after word spread that Leo Trotsky had been murdered at his home with an ice pick, following years of exile. Stalin distanced himself from the murder, but given the timing- Lenin had recently died, and there was a battle for the leadership of the country- many were quick in pointing the finger directly at the future dictator. The official version is that Trotsky was killed by NKVD agent Ramon Mercader, following a struggle in which the former struggled after being hit on the head with the ice pick. Although history books accept that the Man of Steel was directly responsible, many historians still raise feasible issues: was Stalin there to ask Trotsky to subscribe to his own political theories? Was the man dubbed an economic genius murdered at all, or was he kept behind the scenes to aid the development of Stalinism?
The hottest ticket in town
There isn’t much to be said about Davos. It’s in Switzerland. It’s situated on a high valley. It’s particularly cold, most likely. However, toward the end of January every year, the tiny municipality attracts the attention of a huge number of VIPs, business heads and world leaders. Essentially, its the cream of the business and politics crop.
As always the Annual Meeting 2008 will be addressing the future. Topics of discussion are anticipated to be heavily embedded in issues such as the scarcity of resources and global warfare. The cold Swiss winter may be heated by discussions of potential solutions to the world’s problems, by its finest leaders acting as a collective.
2007 German Chancellor, Angela Merkel, set out Germany’s G8 presidency objectives of “growth and responsibility”
2006 Trade officials agree to accelerate talks to achieve a world trade deal. Some 25 trade ministers agreed to move on all key issues – agriculture, services and manufacturing – at the same time
Is interest cooling in biofuels already?
Soaring crude oil prices have made alternative biofuels a hot investment, but enthusiasm for the sector has cooled lately. Is this a bubble set to burst? Not likely, but now could be the time to look beyond the top five countries that lead this area.
4 Germany
5 Spain
Why RFID is nearing its tipping point
The implementation of RFID tracking could revolutionise supply chain logistics. With a lack of cohesive standards, many industry sectors have been slow off the mark, but new schemes being piloted at the moment could lead to far wider application.
RFID tracking is a great idea. Stick a tag on any item, and you can check wherever it is in the world. The potential benefits to the supply chain all around the world are enormous. Some major roadblocks have slowed mass adoption of this panacea– in–waiting, but the technology may finally have reached its tipping point.
RFID allows a company to scan and track radio frequency tags on inpidual items, be they packing cases, pallets, CDs, books or even clothing.
The tags carry Electronic Product Codes that describe what’s inside, who made it and where it has come from. A lack of agreed technology standards has up until now slowed the widespread implementation of RFID. But these barriers are gradually coming down.
There are pilot schemes underway in some of Europe’s most important industry sectors, and the results look promising. The comprehensive roll–out of RFID is starting to look inevitable.
“The technology has evolved dramatically in terms of performance, quality and costs,” says Henri Barthel, coordinator of a European Union–funded project called Bridge, which has been organising pilots. Barthel says that as the technical, commercial and political barriers to RFID come down, the total number of tags purchased annually in Europe will rocket from 144 million in 2007 to 86.7 billion in 2022.
The total number of locations with RFID readers in Europe should increase from a little over 2,500 to around 450,000 during that 15–year period. And the number of RFID readers should increase from a few thousand to more than 6 million, Barthel says.
What’s needed to tip RFID to mass adoption?
1 Agreed standards on how the technology works
2 Scanners and chips that are “plug–and–play” – no thinking required
3 Clear evidence of return on investment “When these three parameters converge there will be massive adoption compared to what we see today,” says Barthel.
Taking cost out is key to mass RFID implementation. Even where pilots show a good return on investment, companies, particularly multinationals, often baulk at the massive investments they would need to deliver a comprehensive RFID–enabled operation.
French retailer Carrefour and its supplier Benedicta are two of the companies involved in pilots. They are tracking a range of reusable assets, including pallets and crates with RFID tags and sharing the information between to increase their efficiencies.
Kaufhof, the major German department store, is sharing RFID–generated information with Gardeur, its garment supplier, and testing the benefits of in–store applications, such as “smart” shelves fitted with RFID readers.
In another pilot, electronics giant Sony is looking for cost– savings and efficiencies in its service operations, using RFID tags to track products and parts between its Spanish factory, its Dutch warehouse hub and its German store and service centres.
Barthel is confident the technology will prove itself and that RFID will reach a mass market. Each RFID solution that the Bridge project nails down helps the movement towards agreed standards and lower cost implementation, says Barthel.
RFID hasn’t got there yet, but it might not be long now.
The death knell for dinosaurs of leadership
Pigeon-holing different types of business professionals is often like shooting fish in a barrel but surprisingly, it usually holds up to scrutiny. Neil Baker discusses the types of personality who often make it – or don’t – in business leadership.
Email is dead… Long live email
Although it has only become a prevalent means of communication in the last 10 to 15 years, email is already showing its age with younger users turning to social networking alternatives. The New Economy looks at the death and rebirth of email.
Dead-mail
Email is too slow. Usage is certainly falling among American teenagers. It was down by eight percent last year, according to research from ComScore Media Metrix. In search of quicker and more fluid ways to stay in touch with friends, teenagers are using tools such as Instant Messaging, SMS texting and Twitter. They only use email to talk to “old people”, according to a study by the Pew Internet and American Life Project.
Email is not cool… but social networking is. Teenagers are turning to sites like MySpace (75 percent of US market) and Facebook (13 percent). Why bother with email, when you can broadcast your life to your “friends”.
Email is full of spam. Bill Gates promised to block it, but couldn’t. Some estimates say as much as 80 percent of email traffic in the US is spam. No communication system can survive a “noise–to–signal” ratio of 80–20. The failure to kill spam is killing email.
Live-mail
No doubt those are compelling reasons to give up on email, if you are a thirteen year–old living in Idaho. But teenagers don’t run the world – yet. Here are some reasons why email is alive and well, and looks like staying that way.
Cool wears off. Teenagers might like “cool” technologies like Twitter, but when they grow up the value of cool gets replaced by the value of useful. Email might not be cool, but it will survive because it is useful. The comScore stats on falling teen email usage quoted above grabbed the headlines, but the same research found that e–mailing by users of all ages was up six percent.
Work gets in the way. Social networking might be fun, but employer patience is running out. The recent popularity of sites such as Facebook, MySpace and Bebo in the UK, for example, is costing corporations close to £6.5bn annually in lost productivity, according to a survey by Global Secure Systems. Chief information security officers said in one study that one of their biggest IT concerns for 2008 was how to manage social networking sites at work. Many estimated that between 15 percent and 20 percent of their current bandwidth is taken up with social networking sites. Another study found that 63 percent of businesses were planning to monitor or limit staff access to such sites and 17 percent plan to ban access at work completely over the next six months.
We are not all monkeys. Texting and messaging are great for what anthropologists call social grooming. Monkeys, for example, form social bonds by picking fleas off each other; humans do it with brief hellos, nods in the street, letting others know we are still alive. Thumb–typed 158–character messages are great for that, but less good at communicating anything more meaningful.
Stem cell technology and precision gene therapy united successfully
A major medical landmark has been reached as stem cell technology and precision gene therapy have been successfully fused in humans for the first time.
The breakthrough could lead to a cure allowing sufferers of genetic diseases to be treated with their own cells.
Private investigations
With government funding and R&D budgets cut as part of austerity drives, the next generation of scientific breakthroughs may be made by amateurs
With deficit cutting a priority in US and Europe, funding in the sciences is suffering. Without the money to continue, projects are being scrapped across all areas, such as the termination of the space shuttle programme by NASA.
It may take a decade for government funding to be able to support pre-recession science funding budgets. For enthusiasts the drive for progress won’t wait that long.
As a result, a number of private and amateur projects have got underway – with big scientific goals on their mind – particularly in the field of rocketry.
Private space travel ventures have been in the works for some time. Richard Branson’s Virgin Galactic, currently at the testing stage, promises to take privileged customers to the edge of space within the next few years. Space Exploration Technologies however, aims to do better. Founded by PayPal creator Elon Musk on the principles of “simplicity, low-cost, and reliability”, SpaceX was set up as a private space venture, with the aim of sending both manned and unmanned vehicles into space.
The company launched its first orbital rocket – Falcon 1 – in 2008. It has since built on this achievement with subsequent flights of its Falcon 9 rocket. The company is targeting the private market for the deployment of orbital equipment at approximately $300m – around 40 percent of the price charged by government programmes. So effective is the company at achieving its goals, NASA has provided funding for SpaceX to build rockets to carry cargo and eventually passengers to the International Space Station, with a launch planned for this coming November.
On an even less grand budget, a Danish team of amateur rocketeers are aiming for manned orbit on a budget of around $40,000. Funded by donations, Copenhagen Suborbitals is already at the testing stage with its rocket, HEAT 4. Unmanned rockets have so far achieved heights of around three kilometres, though tests have experienced notable problems including parachute failure. However, within three to five years it is expected these amateurs will accomplish the equivalent of Yuri Gagarin’s flight in 1961 at a fraction of the costs spent by the Soviet Union.
It’s not only in the field of rocketry where amateurs are having an impact. Sciences ranging from butterfly tracking and conservation to finding cures for Parkinson’s disease and cancer are all being undertaken to greater or lesser success, with the internet proving an indispensible tool in sharing findings and generating support.
Clearly though, there are limits to what can be achieved through amateur science. In August, a Swedish man was arrested by police after a tip off by the Swedish Nuclear Authority. A search of Richard Handl’s flat in Angelholm found radium, americium and uranium. Far from a sinister plot however, the man explained he had been trying to split the atom – in his kitchen.
Handl is said to be a keen amateur physicist and had kept a blog of his progress. He had tried to combine the radioactive elements – bought online as part of old smoke detectors – by immersing them together in 96 percent pure sulphuric acid and heating them on his kitchen stove. He was the one who had contacted the nuclear authority after he began to question the legality of what he was doing.
Up to his arrest, Handl had, luckily, been unsuccessful in his attempts, only managing to create a ‘meltdown’ on his cooker. Police have since released him, finding him to pose no threat to society. This case illustrates that while private endeavour looks set to capitalise on subdued publicly-funded science institutions, amateurs need to set a limit to their ambitions.
